It inhibits the enzyme in the gastric parietal cells, and thereby block the final step of the synthesis of hydrochloric acid. This reduces the level of basal and stimulated secretion regardless of the nature of the stimulus. After a single oral administration of omeprazole effect occurs within the first hour and lasts for 24 hours, the maximum effect is achieved in 2 hours. After discontinuation secretory activity is completely restored in 3-5 days.
Rapidly absorbed from the gastrointestinal tract, peak plasma concentration is reached after 0.5-1 hour. Bioavailability is 30-40%. Plasma protein binding is 90%. Omeprazole is almost completely metabolized in the liver. Write buy deca durabolin online mainly kidneys as metabolites.
-Yazvennaya gastric ulcer and duodenal ulcer.
-Erozivno And ulcerative lesions of gastric and duodenal ulcers associated with NSAID.
-Erozivno And ulcerative lesions of the stomach and duodenum, asotsiirovannye with Helicobacter pylori (in the complex therapy )
-Sindrom Zollinger – Ellison syndrome.
DOSAGE AND ADMINISTRATION Duodenal ulcer exacerbation – 20 mg daily for 2-4 weeks (in resistant cases up to 40 mg per day). Peptic ulcer in the acute phase and the erosive and ulcerative esophagitis – on 20-40 mg daily for 4-8 weeks. Eradication pylori Helicobacter – 20 mg 2 times a day for 7 days in combination with antibacterial agents. anti-treatment of gastric ulcer and duodenal ulcer 12 – 10 -20 mg per day. anti-treatment of reflux esophagitis – 20 mg per day for a long time (up to 6 months). Erosive and ulcerative lesions of the gastrointestinal tract caused by NSAIDs – 20 mg daily for 4-8 weeks. Zollinger-Ellison syndrome – the dose selected individually depending on the initial level of gastric secretions, typically from 60 mg per day. If necessary to increase the dose of 80 -120 mg per day, in which case it is divided into 2 doses.
Do not apply Omitoks in pediatric practice, as well as during pregnancy and lactation. If necessary, the appointment during lactation is necessary to resolve the issue of termination of breastfeeding. Before treatment to rule out malignancy in the upper gastrointestinal tract, reception can mask the symptoms and complicate diagnosis. In patients with severe liver failure buy deca durabolin online daily dose should not exceed 20 mg.
Side effect On the part of the digestive system: nausea, diarrhea or constipation, abdominal pain, dry mouth, taste disturbances, stomatitis, transient increase in the level of “liver” enzymes in the plasma.From the nervous system: headache, dizziness, agitation, drowsiness, insomnia, paresthesias, depression, hallucinations. On the part of the musculoskeletal system: muscle weakness, myalgia, arthralgia.Hematopoietic system: leukopenia, thrombocytopenia. Skin reactions: rash, itching. Other: visual disturbances, peripheral edema, sweating, fever , gynecomastia.
Hypersensitivity to the drug.
INTERACTION WITH OTHER DRUGS
may slow the elimination of some drugs metabolized in the liver by microsomal oxidation (diazepam, phenytoin, indirect anticoagulants).
It slows down the absorption of ketoconazole, ampicillin, iron supplements. Can increase the concentration of clarithromycin in plasma.
Overdose symptoms are blurred vision, drowsiness, irritability, headache, increased sweating, dry mouth, nausea, tachycardia. There is no specific antidote. Treatment is symptomatic.
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