deca durabolin cycle

Tamsulosin is a specific blocker of postsynaptic α 1 -adrenoceptors located in the smooth muscle of the prostate, bladder neck and prostatic urethra. The blockade deca durabolin cycle adrenoceptor tamsulosin reduces the tone of smooth muscles of the prostate, bladder neck and prostatic urethra and improve urine flow. Simultaneously decreased as the emptying symptoms and filling symptoms associated with elevated tone of smooth muscle and detrusor overactivity for benign prostatic hyperplasia.
The ability of tamsulosin affect α 1A subtype adrenoceptor 20 times greater than its ability to interact with the α 1B subtype adrenergic receptors, which are arranged in smooth vascular muscles. Due to its high selectivity, tamsulosin does not cause a clinically significant reduction in systemic blood pressure (BP) in both hypertensive patients and in patients with normal baseline BP.

Tamsulosin is well absorbed in the gut and has almost 100% bioavailability. Absorption of tamsulosin somewhat slowed down after a meal. The same level of absorption can be achieved when the patient receives the drug each time after normal breakfast. Tamsulosin is characterized by linear kinetics. After a single oral 0.4 mg achieved within 6 hours of its preparation the maximum concentration in plasma. After repeated oral administration of 0.4 mg per day equilibrium concentration is reached by the 5th day, and its value is about 2/3 higher than the value of this parameter after a single dose. Distribution:Relationship to plasma proteins – 99%, the volume of distribution is small (about 0.2 l / kg). Metabolism: Tamsulosin is slowly metabolized in the liver with the formation of less active metabolites. Most tamsulosin represented plasma in unmodified form. In the experiment revealed the ability of tamsulosin slightly induce the activity of microsomal liver enzymes. At low and moderate hepatic failure is not required dosing regime correction. Excretion: Tamsulosin and its metabolites are mostly excreted in the urine, with approximately 9% of the drug is excreted unchanged form. The half-life of the drug at a single dose of 0.4 mg after meals is 10 hours, with repeated – 13 hours. in deca durabolin cycle  renal failure does not require dose reduction, if the patient has severe renal insufficiency (creatinine clearance less than 10 ml / min) the appointment of tamsulosin must be made with caution.

Indications for use . Treatment dizuricheskih disorders in benign prostatic hyperplasia.

Contraindications . Hypersensitivity to tamsulosin or any other component of the formulation.
Orthostatic hypotension (including history).
Severe hepatic insufficiency.

Be wary – severe renal insufficiency (creatinine clearance less than 10 mL / min)

Dosage and administration . Inside, after breakfast, drinking water, take 1 capsule (0.4 mg), 1 per day. Chew the capsule is not recommended because this may affect the release rate of the drug.

Side effect . Rarely – dizziness, retrograde ejaculation; in rare cases – orthostatic hypotension, tachycardia / palpitations, fatigue, headache.
On the part of the gastrointestinal tract, in rare cases -. nausea, vomiting, diarrhea, constipation
In very rare cases there may be hypersensitivity reactions – skin rash, itching, angioedema .

Overdose . No reported cases of acute overdose tamsulosin. However, theoretically, an overdose may develop acute BP reduction and compensatory tachycardia, in which case you need to symptomatic therapy. Blood pressure and heart rate may be restored when the person making the horizontal position. If no effect is possible to apply means which increase blood volume deca durabolin cycle  and, if necessary, vasoconstrictors. It is necessary to monitor renal function. It is unlikely that dialysis would be effective as tamsulosin is strongly bound to plasma proteins.
In order to prevent further absorption of the drug it is advisable to gastric lavage, activated charcoal or osmotic laxative, such as sodium sulfate.

Interaction with other drugs . In appointing the drug Omnik® with atenolol, enalapril or nifedipine interactions were found. When applied simultaneously with Omnic cimetidine was a slight increase in the concentration of tamsulosin in blood plasma and furosemide – concentration decrease, but it does not require changing the dose Omnic as the drug concentration is within the normal range. Diazepam, propranolol, trichloromethiazide, chlormadinone, amitriptyline, diclofenac, glibenclamide, simvastatin and warfarin does not alter tamsulosin free fraction in human plasma in vitro. In turn, serves as tamsulosin free fractions of diazepam, propranolol, trichlormethiazide and chlormadinone.
The in vitro studies have not been found at the level of interaction with the hepatic metabolism of amitriptyline, salbutamol, glibenclamide and finasteride. Diclofenac and Warfarin may increase the elimination rate of tamsulosin.
Concurrent administration of other antagonists α 1 adrenoceptor may lead to blood pressure reduction.

Special instructions . As with other α 1 adrenoblokatorov, in the treatment of drug Omnic in some cases, decrease in blood pressure may occur, which can sometimes lead to fainting. At the first signs of orthostatic hypotension (dizziness, weakness), the patient should sit or lie down and remain in that position for as long as the symptoms do not disappear. When surgery for cataracts in patients receiving the drug may develop iris syndrome intraoperative instability eyes (narrow pupil syndrome), it is necessary to consider surgery for preoperative patient preparation and conduct of operations. Before starting deca durabolin cycle  drug therapy, the patient must be examined in order to exclude the presence of other diseases that can cause similar symptoms as benign prostatic hyperplasia. Before you start treatment and regularly during therapy should be performed digital rectal examination and, if necessary, determination of prostate specific antigen (PSA). alphabolin