deca durabolin pills

The drug is rapidly distributed in the extracellular fluid. The deca durabolin pills  volume of distribution is equivalent to the volume of the extracellular fluid. The drug is not metabolized, it is not bound to plasma proteins.
Poluraspredeleniya time is approximately 4 minutes and elimination half-life (T1 / 2) – about 70 minutes. Excreted by the kidneys by glomerular filtration. In patients with impaired renal function (glomerular filtration rate <30 mL / min), T1 / 2 longer in proportion to the degree of reduction of filtration rate. In patients with normal renal function after 4 hours after intravenous injection in gadodiamide urine passes about 85% of the drug administered at 24 hours – 95-98%. Renal and total clearance Omniskana are almost identical, and are similar to those of other substances, completely isolated by glomerular filtration.After administration of 0.1 and 0.3 mmol / kg, revealed no dose-dependent change in the kinetics of the drug.

Indications for use:

Magnetic resonance imaging (MRI) of the brain and spinal cord (tumors, strokes, scarring, vascular pathology) and the whole body.

Contraindications:

Hypersensitivity to Omniskanu and its components. Renal insufficiency (glomerular filtration rate less than 30 mL / min), children’s age (up to 6 months).

Precautions
anemia, especially sickle cell and hemolytic, hemoglobinopathies, hepatic failure.

Pregnancy and lactation: Use during pregnancy There is no experience with Omniskana in humans during pregnancy. Do not use the drug for examination of pregnant women, except in those cases where MRI with contrast enhancement is extremely necessary and it is not possible to replace it with other survey techniques. The use of breast-feeding (lactation) The degree of excretion of the drug in breast milk is unknown. Breast-feeding should be discontinued prior to administration of the drug and its renewal is possible not earlier than 24 hours after the injection Omniskana.

Dosage and administration:

Intravenously, once. Omniskan should be typed into the syringe immediately before use.
For 2 hours before the procedure, the patient should stop eating.
With the introduction of the drug the patient should be in a horizontal position. Within 30 minutes after the procedure is carried out medical supervision of the patient, because Most adverse reactions occur during this period.

Contrasting of the entire body for adult patients, the recommended dosage is usually 0.1 mmol / kg (0.2 ml / kg) or, if necessary (0.6 ml / kg). When the body weight of the subject of more than 100 kg of 20-60 ml of the product is usually sufficient to provide diagnostically adequate contrast.

For children older than 2 years, the recommended dosage is 0.1 mmol / kg (0.2 mL / kg). As for adults, and children required dose should be administered once intravenously. In deca durabolin pills  order to ensure the completeness of administration may be washed with an intravenous catheter of 0.9% sodium chloride solution. Magnetic resonance imaging study of MP with contrast enhancement should be started a few minutes after administration of the drug, depending on the pulse sequences and the study protocol. For MP- studies with contrast enhancement Omniskanom are optimal T1-weighted pulse sequences. The range of use of the magnetic field scanners – from 0.15 to 1.5 Tesla – not revealed the dependence of image contrast values of the field device.

Side effect:

Body as a Whole: fever, chills.
On the part of the digestive tract – loss of appetite, belching, abdominal pain, diarrhea, nausea, vomiting. From the nervous system – dizziness, headache, changes in taste and smell, anxiety, personality disorders, ataxia, incoordination, paresthesias, tremor, blurred vision, loss of consciousness (up to the development of deep coma), tinnitus; drowsiness, rarely (> 0.01% – <0.10%), seizures (up to the development of status epilepticus). . Renal function
From the side of hematopoiesis – asymptomatic reductions in serum iron (within the period of 8 to 48 hours after dosing).
Local reactions: local pain or a feeling of fullness in the injection site.
Others – idiosyncrasy, arthralgia, myalgia, facial flushing , increased sweating.

 

Overdose:

Symptoms: increased manifestations of the described side effects. Treatment is symptomatic. Removed by hemodialysis.

Interaction:
Pharmaceutical incompatible with other drugs.

Special instructions:

With regard to the possibility of anaphylactic shock during administration of the drug is necessary to create all conditions for carrying out an immediate, deca durabolin pills  intensive therapy. Before each use of a contrast agent is necessary to obtain accurate information about the patient, including important laboratory findings (eg, creatinine level in blood serum, electrocardiogram, history of allergy, pregnancy).
Before examining the patient should eliminate violations of water-eletrolitnogo balance and to ensure adequate intake fluid and electrolytes. This applies especially to patients with multiple myeloma, diabetes mellitus, polyuria, or gout, as well as newborns, infants and young children, elderly patients.
The absence of contrast enhancement is not unequivocal evidence of the absence of pathology, as some types of tumors or soft plaques in atherosclerosis is not contrasted. The presence or absence of contrast enhancement can be used for differential diagnosis.
Vials are intended for use only in one patient. With the introduction of other drugs necessary to use a separate syringe and needle.
Unused drug residues shall be destroyed.
Each vial or disposable syringe designed for administering the drug to one patient.
It is not recommended to carry out preliminary testing of individual sensitivity using small doses of the drug, because of the risk of severe hypersensitivity reactions.
patients experiencing the fear of waiting before the procedure requires premedication sedative.
Omniskan distorts the results of the measurement of serum concentrations of calcium and iron in the blood with some colorimetric (complexometric) methods commonly used in hospitals. (It is not recommended deca durabolin pills  to use these methods for 12-24 hours after administration Omniskana). If such studies are needed, it is necessary to use other methods of analysis.