Testosterone is a hormone gene-andro. It is produced in the male gonads in Leydig cells. The deca durabolin results hormone is required for the formation of the testes, prostate, seminal vesicles, and the development of secondary sexual characteristics and tertiary affect spermatogenesis. It has a key role in stimulating and maintaining sexual function in men. The drug has anabolic effect, increases the weight of the skeletal muscles, increases mineral content in bones, stimulates the production of erythropoietin in the kidneys, increases the level of hemoglobin in the blood. In healthy men administration of exogenous testosterone inhibits the release of endogenous hormone by inhibiting secretion of luteinizing hormone (LH). at high doses, the drug inhibits spermatogenesis affecting reverse inhibition of secretion of follicle stimulating hormone (FSH). In men with functional pituitary insufficiency, testosterone eliminates symptoms of hypogonadism. If gipoponadizmom impotence is not caused, the use of the drug is ineffective. Testosterone exerts Introduction women, compared to estrogen antagonistic action. It causes inhibition of gonadotropic pituitary function and inhibits the function of the mammary glands. During treatment, there may be the phenomenon of masculinization.
Selection of testosterone esters is dictated by the different rates of absorption and excretion; providing a continuous, uniform androgenic action of testosterone at 4 weeks after a single administration. Testosterone progshonat provides fast action immediately after the introduction and up to 24 hours. Izokapronat testosterone and testosterone phenylpropionate almost have a similar effect on the duration, which begins in 24 hours and lasts up to 2 weeks. Testosterone kapronat starts its operation at a time when the impact of testosterone phenylpropionate izokapronata and stops. Testosterone in the blood is bound (approximately 98 ‘%) with a specific fraction binding globulin, testosterone and estradiol. Biotransformation occurs in the liver to various 17-keto steroids which are after connection with glucuronic acid or sulfuric acid are excreted in the urine in amounts of about 90%. Since stool output 6% of the dose in the unbound form. Period half-life of testosterone is 10-100 minutes.
For men – replacement therapy in primary and secondary hypogonadism (hypopituitarism, syndrome, post-castration syndrome, oligospermia); male menopause, impotence (impotentia generandi virilis); Androgen deficiency (Addison’s disease, adiposogenital syndrome, pituitary dwarfism), infertility (some species due to violation of spermatogenesis).
For women – osteoporosis (against the background of androgen deficiency), breast cancer, ovarian cancer, dysfunctional bleeding Hyperestrogenism, uterine fibroids, endometriosis , disorders of menopause (together with estrogens), premenstrual syndrome.
Omnadren 250 is sometimes used in various forms of hermaphroditism, when there are indications for the virilization of the external genitalia.
Dosage and administration
injected deep into the gluteal muscle.
Doses set individually depending on the indication and the patient’s response.
Typically prescribed to 1 ml every 4 weeks. The primary male hypogonadism , depending on the degree of deficiency of the sex glands (in accordance with the clinical evaluation and the results of laboratory research) Omnadren 250 is administered intramuscularly every 7-14-21 day. Initially, the drug is administered every 7-14 days, and after reaching the therapeutic effect 1 time in 21 days. Male menopauseOmnadren 250 is administered 1 time in 14 days after the onset of the therapeutic effect -. 1 every 21 days Infertility in men (. Azoospermia oligospermia) Omnadren 250 appoint 2 ml 1 time in two weeks. in the case of painful erection of the penis should be discontinued treatment with the drug. Women with menopause syndrome appoint 1 ml 1 every 2 -3 weeks, breast cancer and ovarian 1-2 ml after 1-2 weeks long treatment.
Endocrine and deca durabolin results urogenital system – women: violation of menstruation and amenorrhea, inhibition of gonadotropin secretion, masculinization; men: Gynecomastia, priapism, oligospermia, impaired spermatogenesis. Leather – hirsutism, male-pattern baldness, acne. Disturbances of water and electrolyte status – sodium retention , chlorine, water, potassium, calcium and inorganic phosphate. The digestive system – nausea, cholestatic jaundice, abnormal liver function, “liver” purpura or tumor of the liver tumors. blood coagulation – inhibition activity of the plasma clotting factors II, V, VII and X , bleeding in patients taking anticoagulant drugs inside, polycythemia. Central nervous system – libido disorders, headaches, anxiety, paresthesia. Metabolic disorders – increase of cholesterol levels in blood plasma. The boys – precocious puberty, premature closure of the epiphyseal bone. Others – inflammation and pain at the injection site.
Individual hypersensitivity to the drug, known or suspected carcinoma of the prostate, gynecomastia, hypercalcemia, hypercalciuria, heart failure, renal or hepatic impairment, the use of boys in the prepubertal period.
Women:. Pregnancy and lactation
Do not use in astenikov and men elderly.
Interaction with other drugs
in patients taking anticoagulants inside, it is necessary to conduct constant monitoring of blood coagulation, while the use of androgenic drugs, especially at the beginning of the treatment or cessation of treatment.
In patients with diabetes androgen drugs can reduce the levels of glucose and insulin requirements.
Application androgenic preparations with corticosteroids or adrenocorticotropic hormone increases the risk of peripheral edema, especially in people with liver or heart.
Sometimes drugs that activate the “liver” enzymes – rifampicin, barbiturates, carbamazepine, salicylates. phenylbutazone, phenytoin, primidone may reduce the effect of testosterone.
Preaarat should not be administered intravenously.
Androgen therapy for breast cancer may be the cause of hypercalcemia associated with stimulation of osteolysis. This process may enhance the metastasis in the skeletal system. The drug should be discontinued With increasing hypercalcemia. Women in the treatment of androgenic drugs need to closely monitor the level of calcium in the urine and blood serum.
In the treatment with high doses of androgen drugs should monitor the level of hemoglobin in the blood and hematocrit.
Symptoms of hepatitis, jaundice or changes in functional parameters of the liver are the reason for the cancellation of androgenic drugs and clarify the etiology of these changes. It is necessary to control the functional state of the liver.
In men, the elderly increases the risk of hypertrophy or prostate cancer. Before and after treatment is necessary to examine the prostate and the PSA level to monitor.
Arisen peripheral edema in patients with diseases of the cardiovascular system, liver or kidney deca durabolin results problems may be a reason for discontinuation of the drug.
Androgen therapy in patients with delayed puberty should be used with caution. It is necessary to monitor the condition of the skeletal system every 6 months.
Use of the drug Omnadren 250 as doping can cause serious side effects. Pregnancy and lactation It is unacceptable to use the drug during pregnancy. If necessary, drug treatment during lactation should stop breastfeeding. Effects on ability vehicle management and maintenance of moving parts . There were no direct impact on the ability of Omnadren 250 vehicle management and maintenance of potentially hazardous machinery. The possible violation of the above functions may occur in connection with the emergence of heart failure.