what is deca durabolin

Long chain what is deca durabolin  fatty acids are partially included in the plasma and tissue lipids. DHA is an important structural component of the phospholipids of cell membranes, eicosapentaenoic acid – a precursor for the synthesis of eicosanoids: prostaglandins, thromboxanes, leukotrienes, and other lipid mediators.

Polyunsaturated fatty acids are omega-3 family influence biophysical characteristics of cell membranes by altering the composition of phospholipids and cholesterol, which improves membrane fluidity. The concomitant increase in the capacity for deformation of blood cells may be an explanation for improving rheological properties of blood when consumed fish oil or introduction Omegaven. Furthermore, polyunsaturated fatty acids omega-3 family of modifying the function of membrane enzyme systems, receptors, and the transfer pulse. Omega-3 fatty acids improve the treatment of pathological disorders in premature infants, as well as inflammatory bowel disease, psoriasis, atopic dermatitis, sepsis, burns, post-operative states of cancer. Omegaven has immunomodeliruyuschy, anti-inflammatory effect: lipid ratio restores inflammatory mediators (including prostaglandin, thromboxanes, leukotrienes, cytokines).

The most important long chain fatty acids are omega-3 family: eicosapentaenoic acid (C20: 5ω-3) and docosahexaenoic acid (C22: 6ω-3). The ability of the human body to synthesize eicosapentaenoic and docosahexaenoic acid is very low. Therefore, eicosapentaenoic acid and docosahexaenoic acid have come from outside in a natural way with food or intravenously.
Glycerol contained in Omegavene used for formation energy or reesterifitsiruetsya together with the free fatty acids in the liver triglyceride formation.
Phospholipids of egg yolk incorporated into the cell membrane, being irreplaceable components to maintain their integrity, or hydrolyzed.

The size of the lipid globules with Omegavenom input and biological properties identical to those of physiological chylomicrons in the blood. In healthy volunteers, male half-life triglycerides administered intravenously Omegavenom was 54 minutes.
The therapeutic effect by intravenous route of administration of omega-3 family of fatty acids characterized by a rapid onset of action and high efficiency for acute diseases.

Indications

  • in the treatment of inflammatory bowel disease, sepsis, burns, cachexia (in cancer, cardiac diseases, etc..), and postoperative conditions with insufficient omega-3 fatty acids.
  • for parenteral nutrition of adults with the inclusion of omega-3 fatty acids, especially eicosapentaenoic and docosahexaenoic acid, when oral or enteral nutrition is impossible, insufficient or contraindicated.

Contraindications

  • Severe what is deca durabolin  hemorrhagic disorders
  • Certain acute and life-threatening conditions such as: collapse and shock, acute phase of myocardial infarction, stroke, embolism, coma of unknown origin
  • Omegaven should not be used in patients who are allergic to fish or egg protein.
  • Childhood

General contraindications for parenteral nutrition: hypokalaemia, hyperhydration, hypotonic dehydration, acidosis.

Precautions
Intravenous Omegaven can cause prolonged bleeding time and inhibition of platelet aggregation. Therefore Omegaven should be administered with caution to patients requiring anticoagulant therapy, even taking into account a possible reduction in the dose of these drugs.
Omegaven should be used with caution in patients with impaired lipid metabolism and uncontrolled diabetes.
Due to lack of experience Omegaven should not be used in patients with severe hepatic or severe renal insufficiency.

Pregnancy and lactation
Omegaven should not be used during pregnancy and lactation, as insufficient data to support its safety in these conditions.

Dosage and administration
for infusion into the central or peripheral vein. The bottle should be shaken before use. Omegaven assigned when / used with other infusion fluids (e.g. solutions of amino acids, carbohydrates) through a conventional system for intravenous infusion should be guaranteed compatibility of solutions and emulsions. Daily dose: 1.2 ml Omegaven per 1 kg of body weight per day = 0, 1-0,2 g of fish oil per 1 kg of body weight. . It is approximately equal to 70-140 ml Omegaven patient weighing 70 kg maximum daily dose: 2 ml / kg / day maximum infusion rate: The rate of infusion should not exceed 0.5 ml / kg / h, which corresponds to 0.05 g of fish oil per 1 kg of body weight per hour. It should not exceed the maximum infusion rate, or a significant increase in the concentration of triglycerides in the blood serum can be observed. Omegaven can be administered simultaneously with other fat emulsions. On the basis of the total recommended daily intake of fat equal 2.1 g / kg body weight, the proportion of fish oil with Omegavenom administered should be 10-20% of the consumption.

Side effects.

  • Intravenous Omegaven can lead to a lengthening of bleeding time and inhibition (slowdown) of platelet aggregation.
  • In rare cases, patients may feel fishy taste in the mouth.

The side effects observed in any of the infusion of fat emulsions:
slight fever, what is deca durabolin  feeling of heat and / or cold, chills, flushing or cyanosis, anorexia, nausea, vomiting, shortness of breath, headache; pain in the chest, back, waist, ossalgia; priapism (in very rare cases), increased or decreased blood pressure, anaphylactic reactions (eg erythema).
Possible signs of metabolic overload must be monitored. The cause may be genetic (individual characteristics and metabolic disorders) or lipid metabolism can affect various preceding disease characterized by varying the speed of lipid metabolism, but this condition is mainly observed when using emulsion based on cottonseed oil.
Metabolic overload can occur following symptoms: hepatomegaly with or without jaundice, change or reduction of some blood coagulation parameters (eg bleeding time, coagulation time, prothrombin time, platelet count), splenomegaly, anemia, leukopenia, thrombocytopenia, bleeding or a tendency to bleeding, a change in the functional liver samples, fever, hyperlipidemia, headache, stomach pain, fatigue, hyperglycemia.
Once these side effects occur or triglyceride levels during infusion than 3 mmol / l, the introduction of any fat emulsion should stop or, if necessary, to continue its lower injection rate.

Interaction with other drugs.
Intravenous Omegaven can cause prolonged bleeding time and inhibition of platelet aggregation. Therefore Omegaven should be administered with caution to patients requiring anticoagulant therapy, even taking into account a possible reduction in the dose of these drugs.
Omegaven can only be mixed with preparations of fat-soluble vitamins (Vitalipid) and water-soluble vitamins (Soluvit) and other fat emulsion (Intralipid, Lipovenoz etc.). Incompatibility Incompatibility may occur when adding multivalent cations (e.g., calcium), especially in combination with heparin.

Specific guidance
is recommended to carry out daily monitoring of the concentration of serum triglycerides. Serum triglycerides during infusion of a fat emulsion should not exceed 3 mg / l. Regularly should be monitored: blood glucose, acid-base status, fluid and electrolyte balance, blood count and bleeding time in patients receiving anticoagulant treatment. how much to inject for weight loss

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